Peptide-Based Nanoparticles for Therapeutic Nucleic Acid Delivery

Gene therapy offers the possibility to skip, repair, or silence faulty genes stimulate immune system fight against disease by delivering therapeutic nucleic acids (NAs) a patient. Compared other drugs protein treatments, NA-based therapies have advantage of being more universal approach designing because versatility NA design. NAs (siRNA, pDNA, mRNA) great potential for applications an immense number indications. However, delivery these exogenous is still challenging and requires specific system. In this context, beside non-viral vectors, cell-penetrating peptides (CPPs) gain interest as systems forming variety nanocomplexes depending on formulation conditions properties used CPPs/NAs. review, we attempt cover most important biophysical biological aspects peptide-based nanoparticles (PBNs) acid formulations The relevant peptide families PBNs in presence described since 2015 will be presented. All able deliver vitro vivo common features, which are characterized defined order obtain from 60 nm 150 with homogeneous dispersity (PdI lower than 0.3) positive charge between +10 mV +40 mV.